Indian Journal of Respiratory Care

IJRC Email      Register      Login

VOLUME 1 , ISSUE 2 ( July-December, 2012 ) > List of Articles

REVIEW ARTICLE

Protective lung ventilation in Acute Respiratory Distress Syndrome: What is new?

Vandana Iyengar

Keywords : Acute respiratory distress syndrome, protective lung ventilation, positive end-expiratory pressure, recruitment manoeuvre

Citation Information : Iyengar V. Protective lung ventilation in Acute Respiratory Distress Syndrome: What is new?. Indian J Respir Care 2012; 1 (2):101-111.

DOI: 10.5005/ijrc-1-1-101

License: NA

Published Online: 01-12-2022

Copyright Statement:  NA


Abstract

Acute respiratory distress syndrome (ARDS) is associated with high mortality and morbidity. Traditional ventilation with large tidal volumes aimed at normalisation of blood gases is usually associated with significant injury to the lungs. Protective lung ventilation (PLV) with smaller tidal volumes, higher levels of positive end-expiratory pressure (PEEP) and control of plateau pressures is the accepted mode of ventilation in patients with ARDS. Recruitment manoeuvres have been part of the protocol in PLV. However, considerable controversy surrounds the optimal PEEP that may be applied to these patients. Similarly, there is no consensus on the usefulness of recruitment manoeuvres in these sick patients. This review tries to find some answers to the best way to use PLV, PEEP and recruitment manoeuvres in patients with ARDS.


HTML PDF Share
  1. Doyle L, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA. Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med 1995; 152:1818-24.
  2. Gattinoni L, Caironi P, Pelosi P, Goodman LR. What has computed tomography taught us about acute respiratory distress syndrome? Am J Respir Crit Care Med 2001; 164:1701-11.
  3. Murphy DB, Cregg N, Tremblay L et al. Adverse ventilatory strategy causes pulmonary-to-systemic translocation of endotoxins. Am J Respir Crit Care Med 2000; 162:27-33.
  4. Slutsky AS, Tremblay LN. Multiple system organ dysfunction: Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 1998; 157:1721-5.
  5. Brower RG, Matthay MA, Morris A et al Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Eng J Med 2000; 342:1301-8.
  6. Haas CF. Mechanical ventilation with lung protective strategies: What works? Crit Care Clin 2011; 27:469- 86.
  7. Brower RG, Lanken PN, Macintyre N et al. Higher versus lower positive end-expiratory pressures in patients with acute respiratory distress syndrome. N Eng J Med 2004; 351:327-36.
  8. Albaiceta GM, Luyando LH, Parra D et al. Inspiratory versus expiratory pressure-volume curves to set end-expiratory pressure in acute lung injury. Intensive Care Med 2005; 31:1370-8.
  9. Lachmann B. Open the lung and keep it open. Intensive Care Med 1992; 18:319-21.
  10. Amato MB, Barbas CS, Medeiros DM et al. Effect of protective lung ventilation strategy on mortality in the acute respiratory distress syndrome. N Eng J Med 1998; 338:347-54.
  11. Mercat A, Richard JC, Vielle B et al. Positive endexpiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome. A randomized controlled trail. JAMA 2008; 299:646-55.
  12. Meade MO, Cook DJ, Guyatt GH et al. Ventilation strategy using low tidal volumes, recruitment maneuvers and high positive end-expiratory pressures for acute lung injury and acute respiratory distress syndrome. A randomized controlled trial. JAMA 2008; 299:637-45.
  13. Briel M, Meade M, Mercat A et al. Higher vs. lower positive end-expiratory pressure in patients with acute respiratory distress syndrome and acute lung injury. JAMA 2010; 303:865-73.
  14. Phoenix SI, Paravastu S, Columb M, Vincent JL, Nirmalan M . Does a higher positive endexpiratory pressure decrease mortality in acute respiratory distress syndrome? A systematic review and meta-analysis. Anesthesiology 2009; 110:1098- 105.
  15. Putensen C, Theuerkauf N, Zinserling J, Wrigge H, Pelosi P. . Meta-analysis: Ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury. Ann Intern Med 2009; 151:566- 76.
  16. Dasenbrook EC, Needham DM, Brower RG, Fan E. Higher PEEP in patients with acute lung injury: A systematic review and meta-analysis. Respir Care 2011; 56:568-75.
  17. Ramnath VR, Hess DR, Thompson BT. Conventional mechanical ventilation in acute lung injury and acute respiratory distress syndrome. Clin Chest Med 2006; 27: 601-613.
  18. Arnal JM, Paquet J, Wysocki M et al. Optimal duration of a sustained inflation recruitment maneuver in ARDS patients. Intensive Care Med 2011; 37:1588-94.
  19. Marini JJ. Recruitment by sustained inflation: time for a change. Intensive Care Med 2011; 37: 1572-4.
  20. Hodgson CL, Tuxen DV, Bailey MJ et al. A positive response to a recruitment maneuver with PEEP titration in patients with ARDS, regardless of transient oxygen desaturation during the maneuver. J Intensive Care Med 2011; 26:41-9.
  21. Oczenski W, Hormann C, Keller C et al. Recruitment maneuvers after appositive end-expiratory pressure trial did not induce sustained effects in early adult respiratory distress syndrome. Anesthesiology 2004; 101:620-5.
  22. Gattinoni L, Casroni P, Cressoni M et al. Lung recruitment in patients with acute respiratory distress syndrome. N Eng J Med 2006; 354:1775- 86.
  23. Brower RG, Morris A, Macintyre N et al. Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Crit Care Med 2003; 31:2592-7.
  24. Fan E, Wilcox ME, Brower RG et al. Recruitment maneuvers for acute lung injury. A systematic review. Am J Respir Crit Care Med 2008; 178:1156-63.
  25. Kacmarek RM, Villar J. Lung recruitment maneuvers during acute respiratory distress syndrome: is it useful? Minerva Anestesiol 2011; 77:85-9.
  26. Borges JB, Okamoto VN, Matos GF et al. Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome. Am J Respir Crit Care Med 2006; 174:268-78.
  27. Maisch S, Reissmann H, Fuellekrug B et al. Compliance and dead space fraction indicate an optimal level of positive end-expiratory pressure after recruitment in anesthetized patients. Anesth Analg 2008; 106:175-81.
  28. Hanson A, Göthberg S, Nilsson K, Larsson LE, Hedenstierna G. VTCO2 and dynamic complianceguided lung recruitment in surfactant depleted piglets: a computed tomography study. Pediatr Crit Care Med 2009; 10:687-92.
  29. Caramez MP, Kacmarek RM, Helmy M et al. A comparison of methods to identify open lung PEEP. Intensive Care Med 2009; 35:740-7.
  30. Grasso S, Stripoli T, De Michele M et al. ARDSnet ventilator protocol and alveolar hyperventilation. Role of positive end-expiratory pressure. Am J Respir Crit Care Med 2007; 176:761-7.
  31. Richard JC, Marini JJ. Transpulmonary pressure as a surrogate of plateau pressure for lung protective strategy: not perfect but more physiologic. Intensive Care Med 2012; 38:339-41.
  32. Talmor D, Sarge T, Malhotra A et al. Mechanical ventilation guided by esophageal pressure in acute lung injury. N Eng J Med 2008; 359:2095-104.
  33. Grasso S, Terragni P, Birocco A et al. ECMO criteria for influenza A (H1N1) - associated ARDS: role of transpulmonary pressure. Intensive Care Med 2012; 38:395-403.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.