Prevalence of Metabolic Syndrome in Chronic Obstructive Pulmonary Disease and its Correlation with Body Mass Index, Airflow Obstruction, Dyspnea, and Exercise Index and C-Reactive Protein
D. Suresh Kumar, Richard Samuel, Viola Savy DSouza, Madhu Keshava Bangera
Body mass index, airflow obstruction, dyspnea, and Exercise index, chronic obstructive pulmonary disease, C-reactive protein, Global Initiative for Chronic Obstructive Lung Disease grade, metabolic syndrome
Citation Information :
Kumar DS, Samuel R, DSouza VS, Bangera MK. Prevalence of Metabolic Syndrome in Chronic Obstructive Pulmonary Disease and its Correlation with Body Mass Index, Airflow Obstruction, Dyspnea, and Exercise Index and C-Reactive Protein. Indian J Respir Care 2022; 11 (4):314-320.
Context: Chronic obstructive pulmonary disease (COPD) is a widespread reason of disease and death in developing countries like India, although it is preventable, controllable, and treatable.
Objectives: We studied the occurrence of metabolic syndrome (MetS) among cases of stable COPD and determined the correlation between stable COPD with MetS and body mass index, airflow obstruction, dyspnea, and exercise (BODE index) and C-reactive protein (CRP) titer.
Methods: The study was a case-control analysis conducted on 90 patients from November 2019 to August 2020.
Results: Seventy percentage of our case population belonged to Global Initiative for Chronic Obstructive Lung Disease (GOLD) Grade 1 and 2. A significant correlation between forced expiratory volume 1 s (FEV1) with body mass index (BMI), triglycerides (TGs), high-density lipoproteins (HDL), systolic blood pressure (SBP), and fasting blood sugar (FBS) was found. The higher the GOLD grade (lower FEV1), the higher the values of BMI, TG, HDL, SBP, and FBS. A negative association with MetS is related to small study population.
Conclusion: Patients with MetS had significantly lower FEV1, higher mean SI, higher mean waist circumference, higher mean BMI, higher mean SBP and diastolic blood pressure, higher FBS, and higher HDL and TG. Patients with MetS showed higher BODE index and CRP titer compared to ones without it. Apart from routine vaccination, assessment of systemic comorbidities for early detection of MetS plays a pivotal role to provide best possible quality of life and utmost care to COPD patients and helps reduce mortality and morbidities of COPD.
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