Indian Journal of Respiratory Care

Register      Login

VOLUME 11 , ISSUE 4 ( October-December, 2022 ) > List of Articles

Original Article

Comorbidities and Vaccination Significantly Influence on Post-Coronavirus Disease 19 Functional and Health Status: A Single-Center Experience from South India

Venkata Ramana Kandi, Tarun Kumar Suvvari, L. V. Simhachalam Kutikuppala, Hemanth Reddy Burugu, Sri Harsha Boppana, Venkata Dinesh Kumar Kandula, Mamtha Jadhav, Mani Kruthika Mantha

Keywords : Coronavirus disease 19, functional status, health status, infection, post-COVID-19, severe acute respiratory syndrome coronavirus-2

Citation Information : Kandi VR, Suvvari TK, Kutikuppala LV, Burugu HR, Boppana SH, Kandula VD, Jadhav M, Mantha MK. Comorbidities and Vaccination Significantly Influence on Post-Coronavirus Disease 19 Functional and Health Status: A Single-Center Experience from South India. Indian J Respir Care 2022; 11 (4):321-326.

DOI: 10.4103/ijrc.ijrc_57_22

License: CC BY-NC-SA 4.0

Published Online: 01-12-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Background: Health-care specialists and clinical researchers worldwide have been concentrating more on the acute and intense phase of the coronavirus disease 19 (COVID-19) infection, but there is an exigency toward the incessant monitoring in the postdischarge period to foresee the long-lasting effects of the disease. The main objective of this study is to evaluate the post-COVID-19 health and functional status (PCFS) and the long-term health implications of severe acute respiratory syndrome coronavirus-2 infection among COVID-19 recovered patients. Materials and Methods: An observational, cross-sectional, and hospital-based study was conducted among the COVID-19 recovered patients. The PCFS scale was used as a study tool to assess the functional status. Data were entered into Excel spreadsheets 2019, and statistical analysis was performed using the SPSS version 24.0. Descriptive statistics were used, and the Chi-square test was used to determine the role of sociodemographic characteristics on questions. The statistical significance level was set at P < 0.05 (two-sided). Results: A total of 80 patients were included in the study and the mean age was 37.03 ± 15.15 years. More than half of the participants (52.5%) showed functional limitations. Fatigue (30%), anxiety (23.75%), and cough (6.25%) were noted to be persistent symptoms reported post-COVID-19 recovery. The majority (88.75%) of the study participants experienced at least one symptom post-COVID-19 and 52.5% have experienced at least one functional limitation. The presence of comorbidities (r = 0.664; likelihood ratio [LR] = 0.968), and vaccination (r = 0.700; LR = 0.611) considerably influenced the PCFS. Conclusion: Our study revealed that there is a significant limitation of PCFS among recovered patients. The presence of comorbidities and vaccination significantly correlated with the PCFS. Standard identification tools, extensive screening, and wide education of consequences related to post-COVID-19 along multicentric and global studies are the need of the hour.


PDF Share
  1. Understanding the long-term health effects of COVID-19. E Clinical Medicine 2020;26:100586.
  2. Simpson R, Robinson L. Rehabilitation after critical illness in people with COVID-19 infection. Am J Phys Med Rehabil 2020;99:470-4.
  3. Boon GJ, Barco S, Bertoletti L, Ghanima W, Huisman MV, Kahn SR, et al. Measuring functional limitations after venous thromboembolism: Optimization of the Post-VTE Functional Status (PVFS) Scale. Thromb Res 2020;190:45-51.
  4. Carfì A, Bernabei R, Landi F, Gemelli Against COVID-19 Post-Acute Care Study Group. Persistent symptoms in patients after acute COVID-19. JAMA 2020;324:603-5.
  5. Pant P, Joshi A, Basnet B, Shrestha BM, Bista NR, Bam N, et al. Prevalence of functional limitation in COVID-19 recovered patients using the Post COVID-19 Functional Status Scale. JNMA J Nepal Med Assoc 2021;59:7-11.
  6. Belli S, Balbi B, Prince I, Cattaneo D, Masocco F, Zaccaria S, et al. Low physical functioning and impaired performance of activities of daily life in COVID-19 patients who survived hospitalisation. Eur Respir J 2020;56:2002096.
  7. Goërtz YM, Van Herck M, Delbressine JM, Vaes AW, Meys R, Machado FV, et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: The post-COVID-19 syndrome? ERJ Open Res 2020;6:00542-2020.
  8. Menges D, Ballouz T, Anagnostopoulos A, Aschmann HE, Domenghino A, Fehr JS, et al. Burden of post-COVID-19 syndrome and implications for healthcare service planning: A population-based cohort study. PLoS One 2021;16:e0254523.
  9. Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, et al. 6-month consequences of COVID-19 in patients discharged from hospital: A cohort study. Lancet 2021;397:220-32.
  10. Bellan M, Soddu D, Balbo PE, Baricich A, Zeppegno P, Avanzi GC, et al. Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge. JAMA Netw Open 2021;4:e2036142.
  11. Klok FA, Boon GJ, Barco S, Endres M, Geelhoed JJ, Knauss S, et al. The Post-COVID-19 Functional Status scale: A tool to measure functional status over time after COVID-19. Eur Respir J 2020;56:2001494.
  12. Pal M, Berhanu G, Desalegn C, Kandi V. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): An update. Cureus 2020;12:e7423.
  13. Yoosefi Lebni J, Abbas J, Moradi F, Salahshoor MR, Chaboksavar F, Irandoost SF, et al. How the COVID-19 pandemic effected economic, social, political, and cultural factors: A lesson from Iran. Int J Soc Psychiatry 2021;67:298-300.
  14. Safiabadi Tali SH, LeBlanc JJ, Sadiq Z, Oyewunmi OD, Camargo C, Nikpour B, et al. Tools and techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/COVID-19 detection. Clin Microbiol Rev 2021;34:e00228-20.
  15. Kandi V, Thungaturthi S, Vadakedath S, Gundu R, Mohapatra RK. Mortality rates of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Cureus 2021;13:e14081.
  16. Mohapatra RK, Pintilie L, Kandi V, Sarangi AK, Das D, Sahu R, et al. The recent challenges of highly contagious COVID-19, causing respiratory infections: Symptoms, diagnosis, transmission, possible vaccines, animal models, and immunotherapy. Chem Biol Drug Des 2020;96:1187-208.
  17. Suvvari TK, Kutikuppala LV, Tsagkaris C, Corriero AC, Kandi V. Post-COVID-19 complications: Multisystemic approach. J Med Virol 2021;93:6451-5.
  18. Neufeld KJ, Leoutsakos JS, Yan H, Lin S, Zabinski JS, Dinglas VD, et al. Fatigue symptoms during the first year following ARDS. Chest 2020;158:999-1007.
  19. Mohamed Hussein AA, Saad M, Zayan HE, Abdelsayed M, Moustafa M, Ezzat AR, et al. Post-COVID-19 functional status: Relation to age, smoking, hospitalization, and previous comorbidities. Ann Thorac Med 2021;16:260-5.
  20. Taboada M, Cariñena A, Moreno E, Rodríguez N, Domínguez MJ, Casal A, et al. Post-COVID-19 functional status six-months after hospitalization. J Infect 2021;82:e31-3.
  21. Curci C, Negrini F, Ferrillo M, Bergonzi R, Bonacci E, Camozzi DM, et al. Functional outcome after inpatient rehabilitation in postintensive care unit COVID-19 patients: Findings and clinical implications from a real-practice retrospective study. Eur J Phys Rehabil Med 2021;57:443-50.
  22. Curci C, Pisano F, Bonacci E, Camozzi DM, Ceravolo C, Bergonzi R, et al. Early rehabilitation in post-acute COVID-19 patients: Data from an Italian COVID-19 Rehabilitation Unit and proposal of a treatment protocol. Eur J Phys Rehabil Med 2020;56:633-41.
  23. Waters A, Hill K, Jenkins S, Johnston C, Mackney J. Discordance between distance ambulated as part of usual care and functional exercise capacity in survivors of critical illness upon intensive care discharge: Observational study. Phys Ther 2015;95:1254-63.
  24. Kohlbrenner D, Benden C, Radtke T. The 1-minute sit-to-stand test in lung transplant candidates: An alternative to the 6-minute walk test. Respir Care 2020;65:437-43.
  25. O'Laughlin KN, Thompson M, Hota B, Gottlieb M, Plumb ID, Chang AM, et al. Study protocol for the Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): A longitudinal study of the medium and long-term sequelae of SARS-CoV-2 infection. PLoS One 2022;17:e0264260.
  26. Hazarika A, Mahajan V, Kajal K, Ray A, Singla K, Sehgal IS, et al. Pulmonary function, mental and physical health in recovered COVID-19 patients requiring invasive versus non-invasive oxygen therapy: A prospective follow-up study post-ICU discharge. Cureus 2021;13:e17756.
  27. Sathyamurthy P, Madhavan S, Pandurangan V. Prevalence, pattern and functional outcome of post COVID-19 syndrome in older adults. Cureus 2021;13:e17189.
  28. Verma H, Shah J, Akhilesh K, Shukla B. Patients' perspective about speech, swallowing and hearing status post-SARS-CoV-2 (COVID-19) recovery: E-survey. Eur Arch Otorhinolaryngol 2022;279:2523-32.
  29. Yamada Y, Kawakami M, Tashiro S, Omori M, Matsuura D, Abe R, et al. Rehabilitation in acute COVID-19 patients: A Japanese retrospective, observational, multi-institutional survey. Arch Phys Med Rehabil 2022;103:929-36.
  30. Clemente-Suárez VJ, Beltrán-Velasco AI, Ramos-Campo DJ, Mielgo-Ayuso J, Nikolaidis PA, Belando N, et al. Physical activity and COVID-19. The basis for an efficient intervention in times of COVID-19 pandemic. Physiol Behav 2022;244:113667.
  31. Botek M, Krejcí J, Valenta M, McKune A, Sládecková B, Konecný P, et al. Molecular hydrogen positively affects physical and respiratory function in acute post-COVID-19 patients: A new perspective in rehabilitation. Int J Environ Res Public Health 2022;19:1992.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.