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VOLUME 11 , ISSUE 4 ( October-December, 2022 ) > List of Articles

Original Article

Relation of Plasma High-Density Lipoproteins-Cholesterol with Sarcopenia in Patients with Chronic Obstructive Pulmonary Disease

Walid Abu-Libdeh, Jeneen Khrais, Laith Suwan, Fares Hamdan, Ahmad Qandil, Aya Abdelfattah Kaml, Ghaith Alsabbagh, Said Alsaied, Mohamed Feras Ebedin, Sahar O. Aburuf, Manahil A. Bakir, Razan A. Awad, Fadwa B. Yasin, Tahir Muhammad, Rizwan Qaisar

Keywords : 8-isoprostanes, chronic obstructive pulmonary disease, C-reactive protein, handgrip strength, High-density lipoprotein-cholesterol, sarcopenia

Citation Information : Abu-Libdeh W, Khrais J, Suwan L, Hamdan F, Qandil A, Kaml AA, Alsabbagh G, Alsaied S, Ebedin MF, Aburuf SO, Bakir MA, Awad RA, Yasin FB, Muhammad T, Qaisar R. Relation of Plasma High-Density Lipoproteins-Cholesterol with Sarcopenia in Patients with Chronic Obstructive Pulmonary Disease. Indian J Respir Care 2022; 11 (4):327-332.

DOI: 10.4103/ijrc.ijrc_62_22

License: CC BY-NC-SA 4.0

Published Online: 01-12-2022

Copyright Statement:  Copyright © 2022; Indian Journal of Respiratory Care.


Background: Plasma high-density lipoproteins-cholesterol (HDL-C) is a marker of metabolic health; however, its association with age-associated muscle loss, termed sarcopenia, is unknown. We evaluated the clinical importance of HDL-C in predicting sarcopenia in patients with chronic obstructive pulmonary disease (COPD). Methods: We investigated male healthy elderly and COPD patients, 54-79 years old (n = 55-59/group) through clinical examination, laboratory investigation, and spirometry. Sarcopenia was evaluated as low handgrip strength (HGS), appendicular skeletal mass index (ASMI), and gait speed. Enzyme-linked immunosorbent assays were used to measure the circulating markers of inflammation (C-reactive protein [CRP]) and oxidative stress (8-isoprostanes). Results: The COPD patients exhibited reduced HGS, ASMI and gait speed, and higher CRP and 8-isoprostanes levels and incidence of sarcopenia than controls (all P < 0.05). Plasma HDL-C levels exhibited significant correlations with CRP, HGS, and 8-isoprostane levels (all P<0.05) but not with ASMI and gait speed in both cohorts. Additionally, plasma HDL-C was an independent predictor of sarcopenia in controls and COPD patients (AUC = 0.631, P<0.05). Conclusion: Altogether, our data show that plasma HDL-C levels are a valuable marker of muscle decline and sarcopenia in healthy elderly and patients with COPD.

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