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VOLUME 12 , ISSUE 4 ( October-December, 2023 ) > List of Articles

Original Article

Investigation of the Pulmonary Function of Patients with Asthma and Chronic Obstructive Pulmonary Disease Following COVID-19 Infection

Azita Tangestaninezhad, Alireza Jafarinezhad, Shaghayegh Hoseindoust, Habib Islami

Keywords : 6-minute walk test, Asthma, Chronic obstructive pulmonary disease, Coronavirus disease of 2019

Citation Information : Tangestaninezhad A, Jafarinezhad A, Hoseindoust S, Islami H. Investigation of the Pulmonary Function of Patients with Asthma and Chronic Obstructive Pulmonary Disease Following COVID-19 Infection. Indian J Respir Care 2023; 12 (4):339-344.

DOI: 10.5005/jp-journals-11010-1083

License: CC BY-NC-SA 4.0

Published Online: 18-01-2024

Copyright Statement:  Copyright © 2023; The Author(s).


Aims and background: In this present study, we aimed to investigate the pulmonary function of patients with asthma and chronic obstructive pulmonary disease (COPD) following coronavirus disease of 2019 (COVID-19) infection. Materials and methods: All data of 266 COVID-19 patients with and without a history of asthma/COPD who were referred to the Razi Hospital, Rasht, Iran, from 2021 to 2022 were collected. Patient self-assessment of the impact of COVID-19 on health using the COPD assessment test (CAT) score criterion in both study groups, asthma control test (ACT) in asthma patients, and modified Medical Research Council (mMRC) in COPD patients were evaluated. All data were analyzed using Statistical Package for the Social Sciences (SPSS) version 26 with a significant level of <0.05. Result: According to our results, the mean age of patients was 51.7 ± 14.1 years old; 51% of them were female, and most of the patients were obese. Hypertension and diabetes were the most common comorbidities. The frequency of 6-minute walking test (6MWT) was higher in patients with asthma/COPD at the time of discharge. From the first to second and third follow-ups, forced expiratory volume in 1 second (FEV1) increased in asthma/COPD groups, and FEV1/forced vital capacity (FVC) decreased in the control group. Also, the CAT score in the first and second follow-ups was worse in asthma/COPD groups compared to the control group. In both studied groups, the self-evaluation of patients using all three questionnaires shows a significant improvement process. Conclusion: A significant improvement in shortness of breath and self-assessment tests was observed in patients with asthma/COPD. However, the results of the 6MWT and self-assessment tests at the time of discharge in these patients were more concerning compared to the control group. Clinical significance: Patients with asthma/COPD were at a similar risk of COVID-19 infection compared to the general population. Females and obese individuals were the majority of the patients. FEV1 in asthma/COPD groups showed improvement in long-term follow-up.

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  1. Morawska L, Cao J. Airborne transmission of SARS-CoV-2: the world should face the reality. Environ Int 2020;139:105730. DOI: 10.1016/j.envint.2020.105730
  2. Mo X, Jian W, Su Z, et al. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge. Eur Respir J 2020;55(6):2001217. DOI: 10.1183/13993003.01217-2020
  3. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382(18):1708–1720. DOI: 10.1056/NEJMoa2002032
  4. Zou L, Ruan F, Huang M, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med 2020;382(12):1177–1179. DOI: 10.1056/NEJMc2001737
  5. Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020;579(7798):270–273. DOI: 10.1038/s41586-020-2012-7
  6. Ni W, Yang X, Yang D, et al. Role of angiotensin-converting enzyme 2(ACE2) in COVID-19. Crit Care 2020;24(1):422. DOI: 10.1186/s13054-020-03120-0
  7. Li J, Wang Y, Zeng Y, et al. Critically ill pregnant patient with COVID-19 and neonatal death within two hours of birth. Int J Gynaecol Obstet 2020;150(1):126–128. DOI: 10.1002/ijgo.13189
  8. Zeinali T, Faraji N, Joukar F, et al. Gut bacteria, bacteriophages, and probiotics: tripartite mutualism to quench the SARS-CoV2 storm. Microb Pathog 2022;170:105704. DOI: 10.1016/j.micpath.2022
  9. Halaji M, Heiat M, Faraji N, et al. Epidemiology of COVID-19: an updated review. J Res Med Sci 2021;26:82. DOI: 10.4103/jrms.JRMS_506_20
  10. Yaghubi T, Shakoori V, Nasiri S, et al. Clinical characteristics and outcomes of COVID-19 patients with a history of cardiovascular disease. J Curr Biomed Reports 2022;3(1):2022. DOI: 10.52547/jcbior.3.1.36
  11. Silverman EK, Crapo JD, Make BJ. Harrison's Principles of Internal Medicine, 21st edition. New York: McGraw-Hill Education; 2022.
  12. Israel E. Asthma. Harrison's Principles of Internal Medicine, 21st edition. New York: McGraw-Hill Education; 2022.
  13. Sunjaya AP, Allida SM, Di Tanna GL, et al. Asthma and COVID-19 risk: a systematic review and meta-analysis. Eur Respir J 2022;59(3).2101209. DOI: 10.1183/13993003.01209-2021
  14. Dong X, Cao YY, Lu XX, et al. Eleven faces of coronavirus disease 2019. Allergy 2020;75(7):1699–1709. DOI: 10.1111/all.14289
  15. Shchikota AM, Pogonchenkova IV, Turova EA, et al. Chronic obstructive pulmonary disease and COVID-19: topical issues. Pul'monologiya 2020;30(5):599–608. DOI: 10.18093/0869-0189-2020-30-5-599-608
  16. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002;166(1):111–117. DOI: 10.1164/ajrccm.166.1.at1102
  17. Halabchi F, Mazaheri R. Six min walk test as a criterion for going to the hospital in suspected COVID-19 patients; is it practical, safe and scientifically justified? Front Emerg Med 2020;4(3):e67–e67.
  18. Pandit R, Vaity C, Mulakavalupil B, et al. Unmasking hypoxia in COVID 19-six minute walk test. J Assoc Physicians India 2020;68(9):50–51.
  19. Frija-Masson J, Debray MP, Gilbert M, et al. Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection. Eur Respir J 2020;56(2):2001754. DOI: 10.1183/13993003.01754-2020
  20. Huang Y, Tan C, Wu J, et al. Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase. Respir Res 2020;21(1):163. DOI: 10.1186/s12931-020-01429-6
  21. Ranu H, Wilde M, Madden B. Pulmonary function tests. Ulster Med J 2011;80(2):84–90.
  22. Chiang J, Mehta K, Amin R. Respiratory diagnostic tools in neuromuscular disease. Children (Basel) 2018;5(6):78. DOI: 10.3390/children5060078
  23. Fumagalli A, Misuraca C, Bianchi A, et al. Pulmonary function in patients surviving to COVID-19 pneumonia. Infection 2021;49(1):153–157. DOI: 10.1007/s15010-020-01474-9
  24. Sibila O, Albacar N, Perea L, et al. Lung function sequelae in COVID-19 patients 3 months after hospital discharge. Arch Bronconeumol 2021;57:59–61. DOI: 10.1016/j.arbres.2021.01.036
  25. Daynes E, Gerlis C, Briggs-Price S, et al. COPD assessment test for the evaluation of COVID-19 symptoms. Thorax 2021;76(2):185–187. DOI: 10.1136/thoraxjnl-2020-215916
  26. Wu X, Liu X, Zhou Y, et al. 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study. Lancet Respir Med 2021;9(7):747–754. DOI: 10.1016/S2213-2600(21)00174-0
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