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VOLUME 13 , ISSUE 2 ( April-June, 2024 ) > List of Articles

CASE REPORT

Neuroendocrine Tumor of Larynx—A Rare Entity: A Case Report

Sanya Jain, Sana Ahuja, Sufian Zaheer

Keywords : Case report, Grade, Larynx, Neuroendocrine carcinoma, Neuroendocrine tumor, Supraglottis, Synaptophysin

Citation Information : Jain S, Ahuja S, Zaheer S. Neuroendocrine Tumor of Larynx—A Rare Entity: A Case Report. Indian J Respir Care 2024; 13 (2):117-120.

DOI: 10.5005/jp-journals-11010-1105

License: CC BY-NC 4.0

Published Online: 18-06-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Neuroendocrine laryngeal neoplasms are uncommon and comprise only 1% of all laryngeal neoplasms. These tumors are characterized by cells showing various degrees of pleomorphism that are arranged in nests and trabeculae containing neurosecretory granules, which show immunohistochemical positivity for synaptophysin, chromogranin, and neuron-specific enolase (NSE). Here, we present a rare case of neuroendocrine tumor (NET) grade III of the supraglottic region. The patient presented with a change in voice for 3 years and difficulty in swallowing solid and liquid both for the last 4 months. Histopathological examination showed a lobular architecture with cells exhibiting moderate pleomorphism and finely stippled chromatin. In immunohistochemistry (IHC), these cells showed positivity for synaptophysin and chromogranin with a Ki-67 index of 25%, thus confirming the diagnosis of NET, grade III.


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