Indian Journal of Respiratory Care

IJRC Email      Register      Login

VOLUME 13 , ISSUE 2 ( April-June, 2024 ) > List of Articles


Neuroendocrine Tumor of Larynx—A Rare Entity: A Case Report

Sanya Jain, Sana Ahuja, Sufian Zaheer

Keywords : Case report, Grade, Larynx, Neuroendocrine carcinoma, Neuroendocrine tumor, Supraglottis, Synaptophysin

Citation Information : Jain S, Ahuja S, Zaheer S. Neuroendocrine Tumor of Larynx—A Rare Entity: A Case Report. Indian J Respir Care 2024; 13 (2):117-120.

DOI: 10.5005/jp-journals-11010-1105

License: CC BY-NC 4.0

Published Online: 18-06-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Neuroendocrine laryngeal neoplasms are uncommon and comprise only 1% of all laryngeal neoplasms. These tumors are characterized by cells showing various degrees of pleomorphism that are arranged in nests and trabeculae containing neurosecretory granules, which show immunohistochemical positivity for synaptophysin, chromogranin, and neuron-specific enolase (NSE). Here, we present a rare case of neuroendocrine tumor (NET) grade III of the supraglottic region. The patient presented with a change in voice for 3 years and difficulty in swallowing solid and liquid both for the last 4 months. Histopathological examination showed a lobular architecture with cells exhibiting moderate pleomorphism and finely stippled chromatin. In immunohistochemistry (IHC), these cells showed positivity for synaptophysin and chromogranin with a Ki-67 index of 25%, thus confirming the diagnosis of NET, grade III.

PDF Share
  1. Ferlito A, Devaney KO, Rinaldo A. Neuroendocrine neoplasms of the larynx: advances in identification, understanding, and management. Oral Oncol 2006;42(8):770–788. DOI: 10.1016/j.oraloncology.2006.01.002
  2. Goldman NC, Hood CI, Singleton GT. Carcinoid of the larynx. Arch Otolaryngol 1969;90(1):64–67. DOI: 10.1001/archotol.1969.00770030066013
  3. Rindi G, Klimstra DS, Abedi-Ardekani B, et al. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol 2018;31(12):1770–1786. DOI: 10.1038/s41379-018-0110-y
  4. Soga J, Osaka M, Yakuwa Y. Laryngeal endocrinomas (carcinoids and relevant neoplasms): analysis of 278 reported cases. J Exp Clin Cancer Res 2002;21(1):5–13. PMID: 12071530.
  5. Van der Laan TP, Plaat BE, van der Laan BF, et al. Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: a meta-analysis of 436 reported cases. Head Neck 2015;37(5):707–715. DOI: 10.1002/hed.23666
  6. Perez-Ordoñez B. Neuroendocrine carcinomas of the larynx and head and neck: challenges in classification and grading. Head Neck Pathol 2018;12(1):1–8. DOI: 10.1007/s12105-018-0894-6
  7. Wenig BM, Hyams VJ, Heffner DK. Moderately differentiated neuroendocrine carcinoma of the larynx: a clinicopathologic study of 54 cases. Cancer 1988;62(12):2658–2676. DOI: 10.1002/1097-0142(19881215)62:12<2658::aid-cncr2820621235>;2-m
  8. Ferlito A, Friedmann I. Review of neuroendocrine carcinomas of the larynx. Ann Otol Rhinol Laryngol 1989;98(10):780–790. DOI: 10.1177/000348948909801006
  9. Bal M, Sharma A, Rane SU, et al. Neuroendocrine neoplasms of the larynx: a clinicopathologic analysis of 27 neuroendocrine tumors and neuroendocrine carcinomas. Head Neck Pathol 2022;16(2):375–387. DOI: 10.1007/s12105-021-01367-9
  10. Ferrarotto R, Testa L, Riechelmann RP, et al. Combination of capecitabine and oxaliplatin is an effective treatment option for advanced neuroendocrine tumors. Rare Tumors 2013;5(3):e35. DOI: 10.4081/rt.2013.e35
  11. Wang KR, Jia YJ, Zhou SH, et al. Cutaneous and subcutaneous metastases from atypical laryngeal carcinoids: case report and review of the literature. Medicine (Baltimore) 2016;95(7):e2796. DOI: 10.1097/MD.0000000000002796
  12. Bräutigam K, Rodriguez-Calero A, Kim-Fuchs C, et al. Update on histological reporting changes in neuroendocrine neoplasms. Curr Oncol Rep 2021;23(6):65. DOI: 10.1007/s11912-021-01062-6
  13. Yuan C, Jiao F, Zhai C, et al. Application of INSM1 in diagnosis and grading of laryngeal neuroendocrine carcinoma. Laryngoscope 2021;131(10):E2662–E2668. DOI: 10.1002/lary.29554
  14. Rai V, Malhotra V, Kumar N, et al. Laryngeal neuroendocrine tumor: atypical presentation. Int J Otorhinolaryngol Clin 2017;9(1):32–34. DOI: 10.5005/jp-journals-10003-1258
  15. Paudel D, Shrestha A, Chettri ST, et al. Neuroendocrine tumor of larynx: a case report. J Coll Med Sci Nepal 2020;16(1):54–56. DOI: 10.3126/jcmsn.v16i1.27133
  16. Y H, X G, F J, et al. Atypical carcinoid of the larynx: a case report. Ear Nose Throat J 2023;102(11):NP556–NP558. DOI: 10.1177/01455613211024868
  17. Mesolella M, Allosso S, Buono S, et al. Neuroendocrine carcinoma of the larynx with Lambert-Eaton myasthenic syndrome: a rare case report and literature review. J Int Med Res 2021;49(5):3000605211014784. DOI: 10.1177/03000605211014784
  18. Zhu Y, Gao L, Meng Y, et al. Laryngeal neuroendocrine carcinomas: a retrospective study of 14 cases. Biomed Res Int 2015;2015:832194. DOI: 10.1155/2015/832194
  19. Feola T, Puliani G, Sesti F, et al. Laryngeal neuroendocrine tumor with elevated serum calcitonin: a diagnostic and therapeutic challenge. Case report and review of literature. Front Endocrinol (Lausanne) 2020;11:397. DOI: 10.3389/fendo.2020.00397
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.