Indian Journal of Respiratory Care

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VOLUME 2 , ISSUE 2 ( July-December, 2013 ) > List of Articles


Diffuse pulmonary calcification syndrome - a case report

Monu Yadav, R Gopinath, Shantveer G Uppin, C Sundaram

Keywords : Calcification, diffuse, nodular, opacities, pulmonary, syndrome

Citation Information : Yadav M, Gopinath R, Uppin SG, Sundaram C. Diffuse pulmonary calcification syndrome - a case report. Indian J Respir Care 2013; 2 (2):332-335.

DOI: 10.5005/jp-journals-11010-02213

License: NA

Published Online: 05-12-2022

Copyright Statement:  NA


Diffuse pulmonary calcification can be (1) metastatic, in which the calcium deposits occur in normal tissues, or (2) dystrophic, in which calcification occurs on injured lung tissue. The pathogenesis of these abnormalities is not fully understood, but hypercalcemia, hyperphosphatemia, alkalosis, and lung damage predispose to calcification and ossification. Standard digital radiography and high resolution computed tomography (HRCT) offer excellent diagnostic sensitivity in the detection of small calcifications inside the lung. We describe the case of a 35 year old male admitted with acute respiratory failure due to acute on chronic lung pathology. His blood culture and bronchial wash cultures were sterile throughout the illness. Bronchial wash culture was negative for acid fast bacilli (AFB), on Gram staining and for any fungal growth. Smears were negative for malignancy. CT scan of the chest showed multiple nodules bilaterally. As all the cultures were sterile, in view of history of unexplained fever, weight loss and unexplained finding of pulmonary nodular lesions, the patient was further investigated on the lines of vasculitic syndromes and the possibility of these syndromes was also ruled out. Postmortem biopsy revealed a diagnosis of diffuse pulmonary calcification syndrome. Diffuse pulmonary calcification is a progressive, normally asymptomatic disease but can lead to critical and fulminant respiratory failure.

  1. Kuhlman FE, Ren H, Hutchins GM, Fishman EK. Fulminant pulmonary calcification complicating renal transplantation: CT demonstration. Radiology 1989; 173:459-60.
  2. Villalobos SR, Becerra RE, Naranjo BF, Martín Juan J. Metastatic pulmonary calcification: a rare cause of interstitial lung disease. Arch Bronconeumol 2003; 39:184-6.
  3. Morkos SK. Regarding metastatic pulmonary calcification in renal failure. Br J Radiol 2002; 75:711-2.
  4. Miyoshi I, Saito T, Kobayashi M, Taguchi H. Pulmonary calcinosis in adult T-cell leukaemia. Br J Haematol 2004; 126:164.
  5. Collins J. CT signs and patterns of lung disease. Radiol Clin North Am 2001; 39:1115-35.
  6. Patel AM, Ryu JH, Reed CE. Hypersensitivity pneumonitis: current concepts and future questions. J Allergy Clin Immunol 2001; 108:661- 70.
  7. British Thoracic Society, Standards of Care Committee. The diagnosis, assessment and treatment of diffuse parenchymal lung disease in adults. Thorax 1999; 54:S1-S28.
  8. Reynolds HY. Diagnostic and management strategies for diffuse interstitial lung disease. Chest 1998; 113:192-202.
  9. Limper AH, Rosenow EC III. Drug-induced interstitial lung disease. Curr Opin Pulm Med 1996; 2:396-404.
  10. Chandrashekharan AN. Assessment and management of vasculitis. Postgrad Medicine 1994;8.
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