There are a limited number of Indian studies which evaluated the efficacy of subglottic suctioning in reducing the occurrence of ventilator associated pneumonia among intubated patients. Aim: To evaluate the efficacy of subglottic suctioning in reducing the occurrence of ventilator associated pneumonia. Methodology: This randomised controlled trial, was conducted in the Medical and Surgical Intensive Care Units. Twenty patients were enrolled, ten in the intervention and ten in the control group. Background variables, Clinical profile and Clinical Pulmonary Infection Score (CPIS) were evaluated. On admission the subjects, who met the inclusion criteria were randomised using lottery method to either intervention or control group. Pretest CPIS assessment was done for both the groups on the day of admission. Post-test CPIS assessment was carried out on the day of extubation or tracheostomy or when the subject had a temperature spike greater than 1020F. Results: There was a significant reduction in the occurrence of ventilator associated pneumonia among patients in the intervention group than in the control group (P < 0.01). Conclusion: The results confirmed that the implementation of subglottic suctioning is effective in reducing the occurrence of ventilator associated pneumonia among intubated patients.