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VOLUME 7 , ISSUE 2 ( July-December, 2018 ) > List of Articles

Original Article

Inspiratory Capacity in Chronic Obstructive Pulmonary Disease: A Measure of Hyperinflation and Relation with Other Parameters – A Cross-Sectional Study

Achal Bharat Parekh, M. Ravish Kshatriya, Nimit V. Khara, Rajiv P. Paliwal, Sateeshkumar N. Patel

Keywords : 6-min walk test, BODE index, chronic obstructive pulmonary disease, dynamic hyperinflation, forced expiratory volume, Global Initiative for Obstructive Lung Disease, inspiratory capacity

Citation Information : Parekh AB, Kshatriya MR, Khara NV, Paliwal RP, Patel SN. Inspiratory Capacity in Chronic Obstructive Pulmonary Disease: A Measure of Hyperinflation and Relation with Other Parameters – A Cross-Sectional Study. Indian J Respir Care 2018; 7 (2):93-96.

DOI: 10.4103/ijrc.ijrc_2_18

License: CC BY-NC-SA 4.0

Published Online: 02-12-2022

Copyright Statement:  Copyright © 2018; Indian Journal of Respiratory Care.


Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Lung hyperinflation or air trapping is the hallmark of COPD and the primary cause of dyspnea, poor quality of life, and advertent disease prognosis associated with the disease. Debates continue to rise against the use of forced expiratory volume 1 as the single-main evaluative parameter for patients with COPD. Inspiratory capacity (IC) together with spirometry on the other hand has been shown to be a dependable parameter that can indicate the presence and management of lung hyperinflation. Patients and Methods: This cross-sectional study included fifty patients of COPD presenting to the department of respiratory medicine. All patients underwent spirometry and 6-min walk test (6MWT). They were grouped according to the GOLD guidelines for airflow limitation, body mass index (BMI), 6MWT, BODE index, number of exacerbations (NoEs), COPD “ABCD” assessment tool, and IC. t-test and one-way analysis of variance were applied. Results: There were 37 males and 13 females. A positive correlation was found between IC and 6MWT and BMI (coefficient of 0.678 and 0.149, respectively). There was a negative correlation between IC and NoEs and BODE index (coefficient of - 0.257 and - 0.631, respectively). IC correlated strongly with the GOLD classification for airflow limitation and combined assessment of COPD. A statistically significant difference between pre- and post-IC values showed IC as the predictor of lung hyperinflation. Conclusion: IC can be used along with 6MWT, BMI, BODE index and NoE for the prognostication and management of COPD.

  1. Albert P, Agusti A, Edwards L, Tal-Singer R, Yates J, Bakke P, et al. Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease. Thorax 2012;67:701-8.
  2. Celli B, ZuWallack R, Wang S, Kesten S. Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes. Chest 2003;124:1743-8.
  3. Dreyse J, Silva F, Díaz O, Borzone G, Lisboa C. Clinical and functional benefits of adding theophylline to a standard treatment with short acting bronchodilators in patients with COPD. Rev Med Chil 2005;133:1211-9.
  4. O'Donnell DE, Voduc N, Fitzpatrick M, Webb KA. Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease. Eur Respir J 2004;24:86-94.
  5. van Noord JA, Aumann JL, Janssens E, Verhaert J, Smeets JJ, Mueller A, et al. Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD. Chest 2006;129:509-17.
  6. O'Donnell DE, Sciurba F, Celli B, Mahler DA, Webb KA, Kalberg CJ, et al. Effect of fluticasone propionate/salmeterol on lung hyperinflation and exercise endurance in COPD. Chest 2006;130:647-56.
  7. Madueño A, Martín A, Péculo JA, Antón E, Paravisini A, León A, et al. Usefulness of inspiratory capacity measurement in COPD patients in the primary care setting. Int J Gen Med 2009;2:219-25.
  8. Marin JM, Carrizo SJ, Gascon M, Sanchez A, Gallego B, Celli BR, et al. Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001;163:1395-9.
  9. Celli BR, Decramer M, Lystig T, Kesten S, Tashkin DP. Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease. Respir Res 2012;13:66.
  10. Ofir D, Laveneziana P, Webb KA, Lam YM, O'Donnell DE. Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;177:622-9.
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