Indian Journal of Respiratory Care

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VOLUME 9 , ISSUE 1 ( January-June, 2020 ) > List of Articles

Original Article

Baseline Vitamin D as a Predictor of Mortality among Hospitalized Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease in an Endemically Vitamin D-Deficient Area in North India

Mohammad Ramzan Bhat, Shabir Ahmad Dar, Mir Waseem, Mir Nadeem

Keywords : Chronic obstructive pulmonary disease, hazard ratio, mortality, Vitamin D

Citation Information : Bhat MR, Dar SA, Waseem M, Nadeem M. Baseline Vitamin D as a Predictor of Mortality among Hospitalized Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease in an Endemically Vitamin D-Deficient Area in North India. Indian J Respir Care 2020; 9 (1):88-93.

DOI: 10.4103/ijrc.ijrc_48_19

License: CC BY-NC-SA 4.0

Published Online: 08-12-2022

Copyright Statement:  Copyright © 2020; Indian Journal of Respiratory Care.


Background: Conflicting data suggest that Vitamin D reduces the risk of developing chronic obstructive pulmonary disease (COPD) and COPD exacerbations. Scant data are available regarding the Vitamin D status in patients with COPD in India where Vitamin D deficiency is rampant. Objectives: We set out to study the role of baseline Vitamin D on the outcome of acute exacerbation of COPD (AECOPD) in terms of exacerbations, hospitalizations, and mortality. Materials and Methods: In a prospective observational design, 147 consenting participants with AECOPD were recruited and serum Vitamin D assessed at admission. The patients were followed for 3 months for treatment outcomes in terms of mortality, readmissions and exacerbations. Standard statistical methods were used to compare the results among those with sufficient and insufficient Vitamin D status at baseline. Results: Out of 147 completely followed participants, 113 (76.9%) were deficient in Vitamin D (mean ± standard deviation = 11.79 ± 8.5 [normal 30–100 ng/ml]). Patients with low Vitamin D were found to have a significantly higher 90-day mortality than those with normal Vitamin D status (P = 0.42; hazard ratio 4.8, P = 0.032). No statistically significant differences were observed in rates of exacerbations or hospital admission. Conclusion: Patients of AECOPD having baseline Vitamin D deficiency at admission have a higher mortality than those with normal Vitamin D level. Thus, Vitamin D level can serve as a prognostic indicator of the outcome of AECOPD. Larger studies are suggested to further study the association and also determine any role of Vitamin D in the treatment of such cases.

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