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VOLUME 9 , ISSUE 1 ( January-June, 2020 ) > List of Articles


Airway Pressure Release Ventilation Benefits in a Patient with Chronic Lymphocytic Leukemia

Oluwasegun Albert, Abdulraheem Alzahrani, Abdullah Almutairi

Keywords : Acute respiratory distress syndrome, airway pressure release ventilation, atelectrauma, barotrauma, chronic lymphocytic leukemia, lung protective strategies, mechanical ventilation, recruitment maneuvers, ventilator-induced lung injury, volutrauma

Citation Information : Albert O, Alzahrani A, Almutairi A. Airway Pressure Release Ventilation Benefits in a Patient with Chronic Lymphocytic Leukemia. Indian J Respir Care 2020; 9 (1):120-125.

DOI: 10.4103/ijrc.ijrc_53_19

License: CC BY-NC-SA 4.0

Published Online: 08-12-2022

Copyright Statement:  Copyright © 2020; Indian Journal of Respiratory Care.


Background: Airway pressure release ventilation (APRV) is a novel mode of mechanical ventilation (MV) used in the treatment of acute respiratory distress syndrome (ARDS) for patients with severe hypoxemia with a strategy to prevent ventilator-induced lung injury (VILI). APRV can avert VILI because it can limit alveolar-distending pressures. This is a case report of a 45-year-old man diagnosed with chronic lymphocytic leukemia who later developed community-acquired pneumonia and ARDS. Methods: APRV was applied successfully. Initially, he was unsuccessfully managed on conventional ventilation using an “open-lung” ventilation strategy (high positive end-expiratory pressure, high respiratory rate, and low tidal volume), recruitment maneuvers, and prone positioning. Results: A change in the ventilation mode to APRV resulted in the reduction of extravascular lung water as indicated by a chest X-ray, improvement in the oxygenation indices, and successful liberation from the ventilator. Conclusion: This case report concluded that APRV is safe in patients diagnosed with ARDS if other “open-lung” MV approaches and prone positioning have failed.

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