Indian Journal of Respiratory Care

IJRC Email      Register      Login

VOLUME 9 , ISSUE 2 ( July-December, 2020 ) > List of Articles

Original Article

Desaturation on 6-Min Walk Test: A Test with High Negative Predictive Value to Rule Out Pulmonary Hypertension in Interstitial Lung Diseases

Vishwas Gupta, Swapnil Manaji Thorve, Pralhad Prabhakar Prabhudesai

Keywords : 6-min walk test, desaturation, interstitial lung diseases, pulmonary hypertension

Citation Information : Gupta V, Thorve SM, Prabhudesai PP. Desaturation on 6-Min Walk Test: A Test with High Negative Predictive Value to Rule Out Pulmonary Hypertension in Interstitial Lung Diseases. Indian J Respir Care 2020; 9 (2):196-198.

DOI: 10.4103/ijrc.ijrc_63_19

License: CC BY-NC-SA 4.0

Published Online: 08-12-2022

Copyright Statement:  Copyright © 2020; Indian Journal of Respiratory Care.


Abstract

Introduction: Pulmonary hypertension (PH) is one of the major complications of interstitial lung diseases (ILDs) that contributes to increased morbidity and mortality. Predicting and promptly diagnosing PH may improve the outcome in these patients. We evaluated the utility of 6-min walk test (6MWT) to predict PH earlier in the course of ILDs. Patients and Methods: A total of 113 patients diagnosed with ILD as per standard investigation protocols were included in this observational study. Patients were evaluated with 6MWT, pulmonary function tests, and two-dimensional echocardiogram. Patients having mean pulmonary arterial pressure >25 mmHg were labeled as PH, and 4% drop from pretest oxygen saturation was considered as significant desaturation. Results: It was observed that 40% of patients with desaturation on 6MWT had PH. None of the patients without significant desaturation had PH. Conclusion: Desaturation on 6MWT is not an early predictor of PH, which is one of the major complications of ILDs. However, it has a high negative predictive value in the prediction of PH in patients with ILD.


HTML PDF Share
  1. Goto K, Arai M, Watanabe A, Hasegawa A, Nakano A, Kurabayashi M. Utility of echocardiography versus BNP level for the prediction of pulmonary arterial pressure in patients with pulmonary arterial hypertension. Int Heart J 2010;51:343-7.
  2. Arcasoy SM, Christie JD, Ferrari VA, Sutton MS, Zisman DA, Blumenthal NP, et al. Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease. Am J Respir Crit Care Med 2003;167:735-40.
  3. Nathan SD, Shlobin OA, Barnett SD, Saggar R, Belperio JA, Ross DJ, et al. Right ventricular systolic pressure by echocardiography as a predictor of pulmonary hypertension in idiopathic pulmonary fibrosis. Respir Med 2008;102:1305-10.
  4. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: Guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002;166:111-7.
  5. ERS Task Force, Palange P, Ward SA, Carlsen KH, Casaburi R, Gallagher CG, et al. Recommendations on the use of exercise testing in clinical practice. Eur Respir J 2007;29:185-209.
  6. Celli BR, Cote CG, Marin JM, Casanova C, Montes de Oca M, Mendez RA, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 2004;350:1005-12.
  7. AARC clinical practice guideline. Exercise testing for evaluation of hypoxemia and/or desaturation. American Association for Respiratory Care. Respir Care 1992;37:907-12.
  8. Chang JA, Curtis JR, Patrick DL, Raghu G. Assessment of health-related quality of life in patients with interstitial lung disease. Chest 1999;116:1175-82.
  9. Kundu S, Mitra S, Ganguly J, Mukherjee S, Ray S, Mitra R. Spectrum of diffuse parenchymal lung diseases with special reference to idiopathic pulmonary fibrosis and connective tissue disease: An eastern India experience. Lung India 2014;31:354-60.
  10. Lama VN, Flaherty KR, Toews GB, Colby TV, Travis WD, Long Q, et al. Prognostic value of desaturation during a 6-minute walk test in idiopathic interstitial pneumonia. Am J Respir Crit Care Med 2003;168:1084-90.
  11. Kumar R, Gupta N, Goel N. Spectrum of interstitial lung disease at a tertiary care centre in India. Pneumonol Alergol Pol 2014;82:218-26.
  12. Baughman RP, Sparkman BK, Lower EE. Six-minute walk test and health status assessment in sarcoidosis. Chest 2007;132:207-13.
  13. Lima MS, Coletta EN, Ferreira RG, Jasinowodolinski D, Arakaki JS, Rodrigues SC, et al. Subacute and chronic hypersensitivity pneumonitis: Histopathological patterns and survival. Respir Med 2009;103:508-15.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.