Citation Information :
Vadi S, Pednekar A, Bajpe S, Sonawane S, Shinde S, Vaishnav Y, Jha S, Wani P, Sanwalka N. Association of Dynamic Changes in Illness Severity Scores Biochemical and Inflammatory Markers with Outcomes in Invasively Ventilated COVID-19 in Resource-limited Settings: A Time-course Study. Indian J Respir Care 2023; 12 (3):222-229.
Background and objectives: No information is available from India on the kinetics of biochemical and inflammatory markers on the outcomes of invasively ventilated coronavirus disease 2019 (COVID-19) patients.
Patients and methods: In a retrospective study on invasively ventilated COVID-19 patients we performed a time-course design to look at the development of organ dysfunction and its association with survival.
Results: A total of 156 patients were studied. Higher acute physiology and chronic health evaluation (APACHE) II scores on day 1 and Sequential Organ Failure Assessment (SOFA)/Simplified Acute Physiology Score (SAPS) II scores were noted in nonsurvivors. Nonsurvivors had significantly higher blood urea nitrogen, neutrophil-lymphocyte ratio, serum ferritin, interleukin (IL)—6, and D dimer levels as compared to survivors (p < 0.05) as a baseline. A higher percentage of nonsurvivors had serum sodium, serum chloride, blood urea nitrogen (BUN), and serum creatinine levels both above and below limits as compared to survivors. A significantly higher percentage of nonsurvivors had higher arterial pressure of carbon dioxide (PaCO2), lower platelet and absolute lymphocyte counts, and multiorgan dysfunction syndrome (MODS) as compared to survivors (p < 0.05). Positive fluid balance was associated with higher mortality.
Conclusion: Variables recorded at baseline and their dynamics during the period of invasive ventilation were correlated with survival.
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