Indian Journal of Respiratory Care

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VOLUME 13 , ISSUE 2 ( April-June, 2024 ) > List of Articles


Syndrome of Inappropriate Antidiuretic Hormone and Antituberculosis Treatment-induced Hepatitis: A Case Report

Kundan Mehta, Manosri Mandadi

Keywords : Antituberculosis treatment, Case report, Hepatitis, Hyponatremia, Syndrome of inappropriate antidiuretic hormone secretion, Tuberculosis

Citation Information : Mehta K, Mandadi M. Syndrome of Inappropriate Antidiuretic Hormone and Antituberculosis Treatment-induced Hepatitis: A Case Report. Indian J Respir Care 2024; 13 (2):128-131.

DOI: 10.5005/jp-journals-11010-1112

License: CC BY-NC 4.0

Published Online: 18-06-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Pulmonary tuberculosis (PTB) is a widespread respiratory infection predominantly found in developing countries, known for its high mortality and morbidity rates. The standard initial treatment for drug-sensitive PTB involves a 2-month regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol (HRZE), followed by 4 months of isoniazid, rifampicin, and ethambutol (HRE). Hepatitis is a prevalent side effect linked to this treatment, emphasizing the need for close monitoring of liver enzymes at the beginning of the regimen. Hyponatremia, a common metabolic abnormality, is frequently observed in tuberculosis (TB) patients. We present a case of a 54-year-old female with drug-sensitive PTB who developed treatment-induced hepatitis and presented with unresponsive hyponatremia. Extensive investigations and radiological examinations revealed no structural anomalies. Laboratory results pointed to elevated serum antidiuretic hormone (ADH) levels, ultimately leading to the diagnosis of syndrome of inappropriate antidiuretic hormone secretion (SIADH) due to ectopic ADH production.

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